Today I will share some Basic Oncology Knowledge I found in my old notebook:
RECIST 1.1:
Complete Response (CR): Disappearance of all non-nodal target lesion
Partial Response (PR) : At least 30% decrease in the sum of diameters of target lesions compared with the baseline sum diameters.
Progression Disease (PD): At least 20% increase in the sum of diameters of all target lesions compared with the smallest sum ever reported (Nadir) during all follow up studies
or present of new lesions or a greater than 5mm increase.
Stable Disease(SD): Criteria for CR, PR, and PD are not met for at least 6 weeks, 42 days.
Nadir Size: The smallest Sum of Lesion Diameter recorded during treatment.

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Special Parameters in Oncology:
Best Overall Repsonse= Min(CR, PR SD)
Duration of Response (by months):
(Min(Progression Date, Death Date) – (Best overall Response Date) +1)/30.43
Time to Treatment Failure:
(Min(End of study, Progression Date, Death Date)- Randomization Date+1)/30.43
⭐Overall Survival Time, OS:
(Last Contact date- Randomized date +1)/ 30.43
⭐Progression Free Survival, PFS:
(Min(Progression Date, Death Date)- Randomization date +1)/30.43
Time to Tumor Progression, TTP:
(First Progression Date- Randomization Date+1) /30.43
Overall Response Rate(ORR): CR + CRu +PR
It is the Primary Efficacy Endpoints for many Clinical Studies because it shows a direct measurement of drug’s antitumor activity. It is the percentage of people who experience a decrease in the size of the solid tumor (or amount for blood cancer ) of a predefined amount for a minimum time period.
Five Year Survival Rate:
The Percentage of people in a study who are still alive for 5 years after the cancer treatment.
Disease Control Rate, DCR:
DCR= CR+PR +SD
Median Overall Survival:
the time at which half of the people enrolled in the clinical study is still alive.
Median PFS:
The time at which half of the people enrolled in the clinical study are still alive or not
Note: These are some generalized the definitions and concepts, it might vary from different study designs.
Happy Studying 🌿 !!!