Today I will share some Basic Oncology Knowledge I found in my old notebook:
Complete Response (CR): Disappearance of all non-nodal target lesion
Partial Response (PR) : At least 30% decrease in the sum of diameters of target lesions compared with the baseline sum diameters.
Progression Disease (PD): At least 20% increase in the sum of diameters of all target lesions compared with the smallest sum ever reported (Nadir) during all follow up studies
or present of new lesions or a greater than 5mm increase.
Stable Disease(SD): Criteria for CR, PR, and PD are not met for at least 6 weeks, 42 days.
Nadir Size: The smallest Sum of Lesion Diameter recorded during treatment.
Special Parameters in Oncology:
Best Overall Repsonse= Min(CR, PR SD)
Duration of Response (by months):
(Min(Progression Date, Death Date) – (Best overall Response Date) +1)/30.43
Time to Treatment Failure:
(Min(End of study, Progression Date, Death Date)- Randomization Date+1)/30.43
⭐Overall Survival Time, OS:
(Last Contact date- Randomized date +1)/ 30.43
⭐Progression Free Survival, PFS:
(Min(Progression Date, Death Date)- Randomization date +1)/30.43
Time to Tumor Progression, TTP:
(First Progression Date- Randomization Date+1) /30.43
Overall Response Rate(ORR): CR + CRu +PR
It is the Primary Efficacy Endpoints for many Clinical Studies because it shows a direct measurement of drug’s antitumor activity. It is the percentage of people who experience a decrease in the size of the solid tumor (or amount for blood cancer ) of a predefined amount for a minimum time period.
Five Year Survival Rate:
The Percentage of people in a study who are still alive for 5 years after the cancer treatment.
Disease Control Rate, DCR:
DCR= CR+PR +SD
Median Overall Survival:
the time at which half of the people enrolled in the clinical study is still alive.
The time at which half of the people enrolled in the clinical study are still alive or not
Note: These are some generalized the definitions and concepts, it might vary from different study designs.
Happy Studying 🌿 !!!