SAS Baseline

SAS Day 21: Baseline Value

Background:

How do we decide if the Weight Loss program/drug is effective or the laser operation improves the vision? Usually, we compare the weights before and after a program or track the vision before and after the eye laser surgery. The Change From Baseline is a critical measurement of efficacy analysis. Therefore, it is very crucial to record the correct baseline records.

Baseline Definition:
The last non-missing record before or on the day of treatment.

Problem:
Generate the baseline information with a dummy ADEFF  dataset.

suju / Pixabay

Solutions: 

  • Create Baseline records with SAS function Merge 
    1. Output Base records
     2. Select the Baseline values
     3. Merge with the Original datasets
     4. Clean the datasets
data base pbase;
set eff1;
if avisitn<=1 then output base;
else output pbase;
run;

proc sort data=base ;
by usubjid paramcd avisitn;
run;

**Baseline values: last non-missing value before or on the first treatment.;
data base1(keep=usubjid aval paramcd base avisitn rename=(avisitn=avisitn1));
set base(where=(aval ne . ));
by usubjid paramcd avisitn;
if last.paramcd;
rename aval=base;
run;

**merge with original dataset;
data all;
merge eff1(in=a) base1(in=b);
by usubjid paramcd;
*if a and avisitn<avisitn1 then base=.;
if a;
run;

data all;
set all;
if avisitn< avisitn1 then base=.;
run;

 

Output Dataset:

 

  •   Create Baseline records with SAS step Retain 
    Note: Retain is an easier method with the Definite Avisitn number, or it can get messy.
data base2;
set eff1;
by usubjid paramcd avisitn;
retain base;
if first.paramcd then do;
base=.; end;
if avisitn=1 then do ; base=aval; end;
run;

 

Output dataset:

 

Summary:

In the clinical industry, the dataset could be more complicated, I prefer to use the Merge method if the dataset structure is complex. If the data is clean and straightforward with a definitive avisitn for baseline, Retain is a better choice.

Note: there are might be various conditions and restrictions for the baseline, such as a test on the same date but different timepoint.

 

Happy studying!! 🤟

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